Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1976682..1977333 Replicon chromosome
Accession NZ_CP099344
Organism Escherichia marmotae strain RHB35-E2-C08

Toxin (Protein)


Gene name cptA Uniprot ID A0A370V2T3
Locus tag NFK54_RS09805 Protein ID WP_000244789.1
Coordinates 1976682..1977086 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag NFK54_RS09810 Protein ID WP_000354045.1
Coordinates 1977067..1977333 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK54_RS09785 (1972646) 1972646..1974379 - 1734 WP_279283594.1 single-stranded-DNA-specific exonuclease RecJ -
NFK54_RS09790 (1974385) 1974385..1975095 - 711 WP_000715232.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK54_RS09795 (1975120) 1975120..1976016 - 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
NFK54_RS09800 (1976127) 1976127..1976648 + 522 WP_001055874.1 flavodoxin FldB -
NFK54_RS09805 (1976682) 1976682..1977086 - 405 WP_000244789.1 protein YgfX Toxin
NFK54_RS09810 (1977067) 1977067..1977333 - 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
NFK54_RS09815 (1977586) 1977586..1978566 + 981 WP_000886070.1 tRNA-modifying protein YgfZ -
NFK54_RS09820 (1978713) 1978713..1979372 - 660 WP_001517030.1 hemolysin III family protein -
NFK54_RS09825 (1979535) 1979535..1979846 - 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
NFK54_RS09830 (1979891) 1979891..1981324 + 1434 WP_279283595.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15987.93 Da        Isoelectric Point: 11.5202

>T248557 WP_000244789.1 NZ_CP099344:c1977086-1976682 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIR

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT248557 WP_000354045.1 NZ_CP099344:c1977333-1977067 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370V2T3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References