Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 668138..668776 Replicon chromosome
Accession NZ_CP099344
Organism Escherichia marmotae strain RHB35-E2-C08

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NFK54_RS03420 Protein ID WP_000813795.1
Coordinates 668600..668776 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFK54_RS03415 Protein ID WP_077627724.1
Coordinates 668138..668554 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK54_RS03395 (663293) 663293..664234 - 942 WP_279283435.1 ABC transporter permease -
NFK54_RS03400 (664235) 664235..665248 - 1014 WP_016248715.1 ABC transporter ATP-binding protein -
NFK54_RS03405 (665266) 665266..666411 - 1146 WP_000047463.1 ABC transporter substrate-binding protein -
NFK54_RS03410 (666650) 666650..668059 - 1410 WP_107179918.1 PLP-dependent aminotransferase family protein -
NFK54_RS03415 (668138) 668138..668554 - 417 WP_077627724.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NFK54_RS03420 (668600) 668600..668776 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NFK54_RS03425 (668998) 668998..669228 + 231 WP_000494240.1 DUF2554 family protein -
NFK54_RS03430 (669322) 669322..671283 - 1962 WP_279283640.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NFK54_RS03435 (671356) 671356..671892 - 537 WP_000429073.1 XRE family transcriptional regulator -
NFK54_RS03440 (671984) 671984..673156 + 1173 WP_024191882.1 benzoate/H(+) symporter BenE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T248555 WP_000813795.1 NZ_CP099344:c668776-668600 [Escherichia marmotae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15250.62 Da        Isoelectric Point: 4.5908

>AT248555 WP_077627724.1 NZ_CP099344:c668554-668138 [Escherichia marmotae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNNNDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References