Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 44132..44733 Replicon plasmid unnamed2
Accession NZ_CP099340
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag NFK94_RS22605 Protein ID WP_001216045.1
Coordinates 44132..44512 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NFK94_RS22610 Protein ID WP_001190712.1
Coordinates 44512..44733 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS22575 (NFK94_22545) 39270..39371 - 102 Protein_39 transcriptional regulator -
NFK94_RS22580 (NFK94_22550) 39584..41068 - 1485 WP_279279864.1 terminase -
NFK94_RS22585 (NFK94_22555) 41068..42249 - 1182 WP_279279865.1 terminase -
NFK94_RS22590 (NFK94_22560) 42336..42788 - 453 WP_169711153.1 Late promoter-activating protein -
NFK94_RS22595 (NFK94_22565) 42877..43920 - 1044 WP_000648835.1 DUF968 domain-containing protein -
NFK94_RS22600 (NFK94_22570) 43948..44127 - 180 WP_000113018.1 hypothetical protein -
NFK94_RS22605 (NFK94_22575) 44132..44512 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NFK94_RS22610 (NFK94_22580) 44512..44733 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NFK94_RS22615 (NFK94_22585) 45119..46099 - 981 WP_000019434.1 IS5-like element ISKpn26 family transposase -
NFK94_RS22620 (NFK94_22590) 46362..47750 + 1389 WP_001207923.1 nitrate/nitrite transporter NarU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99935 99935
- flank IS/Tn - - 45119..46099 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T248545 WP_001216045.1 NZ_CP099340:c44512-44132 [Escherichia fergusonii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT248545 WP_001190712.1 NZ_CP099340:c44733-44512 [Escherichia fergusonii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References