Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 16141..16688 Replicon plasmid unnamed1
Accession NZ_CP099339
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NFK94_RS21855 Protein ID WP_244442846.1
Coordinates 16410..16688 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag NFK94_RS21850 Protein ID WP_000079941.1
Coordinates 16141..16410 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS21825 (12378) 12378..12791 - 414 Protein_12 IS91 family transposase -
NFK94_RS21830 (12772) 12772..13044 - 273 WP_000019163.1 hypothetical protein -
NFK94_RS21835 (13258) 13258..14073 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
NFK94_RS21840 (14160) 14160..14402 + 243 Protein_15 phosphoglucosamine mutase -
NFK94_RS21845 (14638) 14638..15783 - 1146 Protein_16 IS91-like element ISVsa3 family transposase -
NFK94_RS21850 (16141) 16141..16410 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NFK94_RS21855 (16410) 16410..16688 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
NFK94_RS21860 (16728) 16728..17576 + 849 WP_021265674.1 3'-5' exonuclease -
NFK94_RS21865 (17693) 17693..18166 + 474 WP_001334658.1 hypothetical protein -
NFK94_RS21870 (18643) 18643..18909 - 267 WP_000955263.1 hypothetical protein -
NFK94_RS21875 (18909) 18909..19403 - 495 WP_001459505.1 hypothetical protein -
NFK94_RS21880 (19459) 19459..20061 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA1 / ant(3'')-Ia / blaTEM-1B / sul2 - 1..108225 108225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T248540 WP_244442846.1 NZ_CP099339:16410-16688 [Escherichia fergusonii]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT248540 WP_000079941.1 NZ_CP099339:16141-16410 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References