Detailed information of TA system TA024854

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1400278..1400770
• Replicon: chromosome
• Accession: NC_014363
• Organism: Olsenella uli DSM 7084

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: E1QW35
• Locus tag: OLSU_RS06160
• Protein ID: WP_013252090.1
• Coordinates: 1400278..1400550 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: X8HUM6
• Locus tag: OLSU_RS06165
• Protein ID: WP_013252091.1
• Coordinates: 1400534..1400770 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLSU_RS06135	1395740..1396510	-	771	WP_013252084.1	ABC transporter ATP-binding protein	-
OLSU_RS09635	1396543..1396698	-	156	WP_013252085.1	hypothetical protein	-
OLSU_RS06140	1396912..1397997	-	1086	WP_013252086.1	sensor histidine kinase	-
OLSU_RS06145	1397994..1398662	-	669	WP_013252087.1	response regulator transcription factor	-
OLSU_RS09120	1398730..1399578	-	849	WP_013252088.1	hypothetical protein	-
OLSU_RS06160	1400278..1400550	-	273	WP_013252090.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OLSU_RS06165	1400534..1400770	-	237	WP_013252091.1	hypothetical protein	Antitoxin
OLSU_RS09125	1401106..1401399	-	294	WP_162260679.1	helix-turn-helix transcriptional regulator	-
OLSU_RS09640	1401643..1401789	+	147	WP_156407852.1	hypothetical protein	-
OLSU_RS06175	1401799..1403361	+	1563	WP_013252093.1	terminase	-
OLSU_RS06180	1403398..1403613	+	216	WP_013252094.1	hypothetical protein	-
OLSU_RS09645	1403610..1403786	-	177	WP_013252095.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10662.34 Da
• Isoelectric Point: 10.8094

>T24854 WP_013252090.1 NC_014363:c1400550-1400278 [Olsenella uli DSM 7084]
VAWRIKFTKAADKALRRLDRSVSSRILDELESVSKLEDPRTRGRALRHNLSGLWRYRVGDHRIVCDMEDEVLLVLVVDVA
HRREVYKRHK

Nucleotide

• Length: 273 bp

>T24854 NC_014363:c1400550-1400278 [Olsenella uli DSM 7084]
GTGGCCTGGAGGATTAAGTTCACAAAGGCCGCCGACAAGGCCCTGCGACGGCTCGATCGCTCGGTCTCGTCGAGGATTCT
CGACGAGCTTGAGAGTGTGTCGAAACTCGAAGACCCCCGCACAAGAGGAAGGGCCCTGAGACACAACCTGTCGGGCTTGT
GGCGCTATCGGGTCGGCGACCACCGCATCGTGTGCGACATGGAGGACGAGGTTCTCTTGGTTCTCGTGGTCGATGTGGCC
CACAGGCGCGAGGTCTACAAGCGCCACAAATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8984.11 Da
• Isoelectric Point: 4.5216

>AT24854 WP_013252091.1 NC_014363:c1400770-1400534 [Olsenella uli DSM 7084]
METATAALRMPKELVARYDQLAKSTGRTKTFYMTEALAESIDRLEYEYGILKDIEDYRAGRLETYSLDEVRAHCGLED

Nucleotide

• Length: 237 bp

>AT24854 NC_014363:c1400770-1400534 [Olsenella uli DSM 7084]
ATGGAAACTGCGACTGCGGCATTGAGAATGCCTAAGGAGCTGGTCGCAAGGTACGACCAGCTGGCAAAGTCTACGGGGCG
CACGAAGACGTTCTATATGACCGAGGCCCTTGCGGAGTCCATCGACAGGCTCGAGTACGAGTACGGAATCCTCAAGGACA
TCGAAGACTATCGAGCGGGGCGGCTAGAGACCTACAGCCTCGATGAGGTGAGGGCGCACTGTGGCCTGGAGGATTAA

Structures

Toxin

• AlphaFold DB: E1QW35

Antitoxin

• AlphaFold DB: X8HUM6