Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3514942..3515596 Replicon chromosome
Accession NZ_CP099338
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NFK94_RS17085 Protein ID WP_000244781.1
Coordinates 3514942..3515349 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NFK94_RS17090 Protein ID WP_000354046.1
Coordinates 3515330..3515596 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS17065 (3510899) 3510899..3512632 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
NFK94_RS17070 (3512638) 3512638..3513348 - 711 WP_000715223.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK94_RS17075 (3513373) 3513373..3514269 - 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
NFK94_RS17080 (3514381) 3514381..3514902 + 522 WP_001055874.1 flavodoxin FldB -
NFK94_RS17085 (3514942) 3514942..3515349 - 408 WP_000244781.1 protein YgfX Toxin
NFK94_RS17090 (3515330) 3515330..3515596 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NFK94_RS17095 (3515848) 3515848..3516828 + 981 WP_000886103.1 tRNA-modifying protein YgfZ -
NFK94_RS17100 (3517024) 3517024..3517683 - 660 WP_000250283.1 hemolysin III family protein -
NFK94_RS17105 (3517847) 3517847..3518158 - 312 WP_001182961.1 N(4)-acetylcytidine aminohydrolase -
NFK94_RS17110 (3518203) 3518203..3519636 + 1434 WP_046083325.1 6-phospho-beta-glucosidase BglA -
NFK94_RS17115 (3519684) 3519684..3520577 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T248534 WP_000244781.1 NZ_CP099338:c3515349-3514942 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT248534 WP_000354046.1 NZ_CP099338:c3515596-3515330 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References