Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3238523..3239142 Replicon chromosome
Accession NZ_CP099338
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFK94_RS15610 Protein ID WP_001280991.1
Coordinates 3238924..3239142 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag NFK94_RS15605 Protein ID WP_000344803.1
Coordinates 3238523..3238897 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS15595 (3233655) 3233655..3234848 + 1194 WP_279279692.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFK94_RS15600 (3234871) 3234871..3238020 + 3150 WP_001132493.1 efflux RND transporter permease AcrB -
NFK94_RS15605 (3238523) 3238523..3238897 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
NFK94_RS15610 (3238924) 3238924..3239142 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NFK94_RS15615 (3239639) 3239639..3240109 + 471 WP_279279846.1 YlaC family protein -
NFK94_RS15620 (3240248) 3240248..3241798 + 1551 WP_001260376.1 EAL domain-containing protein -
NFK94_RS15625 (3241840) 3241840..3242193 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NFK94_RS15635 (3242572) 3242572..3242883 + 312 WP_000409911.1 MGMT family protein -
NFK94_RS15640 (3242914) 3242914..3243486 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248533 WP_001280991.1 NZ_CP099338:3238924-3239142 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT248533 WP_000344803.1 NZ_CP099338:3238523-3238897 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References