Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 988000..988583 Replicon chromosome
Accession NZ_CP099338
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name mazF Uniprot ID V0SV58
Locus tag NFK94_RS04815 Protein ID WP_000254750.1
Coordinates 988248..988583 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag NFK94_RS04810 Protein ID WP_000581937.1
Coordinates 988000..988248 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS04800 (984339) 984339..985637 + 1299 WP_104920143.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
NFK94_RS04805 (985688) 985688..987922 + 2235 WP_000226844.1 GTP diphosphokinase -
NFK94_RS04810 (988000) 988000..988248 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NFK94_RS04815 (988248) 988248..988583 + 336 WP_000254750.1 endoribonuclease MazF Toxin
NFK94_RS04820 (988654) 988654..989445 + 792 WP_001071671.1 nucleoside triphosphate pyrophosphohydrolase -
NFK94_RS04825 (989673) 989673..991310 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
NFK94_RS04830 (991398) 991398..992696 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12067.95 Da        Isoelectric Point: 8.2618

>T248524 WP_000254750.1 NZ_CP099338:988248-988583 [Escherichia fergusonii]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT248524 WP_000581937.1 NZ_CP099338:988000-988248 [Escherichia fergusonii]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SV58

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References