Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 748266..748816 Replicon chromosome
Accession NZ_CP099338
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag NFK94_RS03730 Protein ID WP_279279780.1
Coordinates 748502..748816 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag NFK94_RS03725 Protein ID WP_000125566.1
Coordinates 748266..748499 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS03700 (743338) 743338..743625 + 288 WP_000203741.1 ferredoxin-like protein FixX -
NFK94_RS03705 (743684) 743684..745015 + 1332 WP_279279779.1 MFS transporter -
NFK94_RS03710 (745123) 745123..745653 + 531 WP_000600701.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
NFK94_RS03715 (745646) 745646..747508 + 1863 WP_104919956.1 glutathione-regulated potassium-efflux system protein KefC -
NFK94_RS03720 (747701) 747701..748180 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
NFK94_RS03725 (748266) 748266..748499 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NFK94_RS03730 (748502) 748502..748816 + 315 WP_279279780.1 CcdB family protein Toxin
NFK94_RS03735 (748813) 748813..749661 - 849 WP_000257189.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
NFK94_RS03740 (749668) 749668..750045 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
NFK94_RS03745 (750048) 750048..750869 - 822 WP_001065388.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NFK94_RS03750 (750866) 750866..751855 - 990 WP_104918215.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
NFK94_RS03755 (751855) 751855..753141 - 1287 WP_104919957.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11750.75 Da        Isoelectric Point: 8.0666

>T248523 WP_279279780.1 NZ_CP099338:748502-748816 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDVSAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT248523 WP_000125566.1 NZ_CP099338:748266-748499 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References