Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 2948..3549 Replicon plasmid unnamed3
Accession NZ_CP099334
Organism Escherichia fergusonii strain RHB44-C03

Toxin (Protein)


Gene name doc Uniprot ID F0JYA5
Locus tag NFK96_RS22740 Protein ID WP_001216044.1
Coordinates 2948..3328 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NFK96_RS22745 Protein ID WP_001190712.1
Coordinates 3328..3549 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK96_RS22725 (NFK96_22680) 1152..1604 - 453 WP_001312282.1 late promoter-activating protein (Gp10) -
NFK96_RS22730 (NFK96_22685) 1693..2736 - 1044 WP_000648835.1 DUF968 domain-containing protein -
NFK96_RS22735 (NFK96_22690) 2764..2943 - 180 WP_000113018.1 hypothetical protein -
NFK96_RS22740 (NFK96_22695) 2948..3328 - 381 WP_001216044.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NFK96_RS22745 (NFK96_22700) 3328..3549 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NFK96_RS22750 (NFK96_22705) 3935..4915 - 981 WP_279284741.1 IS5-like element ISKpn26 family transposase -
NFK96_RS22755 (NFK96_22710) 5178..6566 + 1389 WP_001207923.1 nitrate/nitrite transporter NarU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89104 89104
- flank IS/Tn - - 3935..4915 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13544.28 Da        Isoelectric Point: 5.6343

>T248518 WP_001216044.1 NZ_CP099334:c3328-2948 [Escherichia fergusonii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVAATLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT248518 WP_001190712.1 NZ_CP099334:c3549-3328 [Escherichia fergusonii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6Y6HMN5

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References