Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 27301..27944 Replicon plasmid unnamed2
Accession NZ_CP099333
Organism Escherichia fergusonii strain RHB44-C03

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag NFK96_RS22345 Protein ID WP_001044768.1
Coordinates 27301..27717 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag NFK96_RS22350 Protein ID WP_001261287.1
Coordinates 27714..27944 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK96_RS22330 (NFK96_22285) 23800..24390 - 591 WP_000194575.1 hypothetical protein -
NFK96_RS22335 (NFK96_22290) 24390..24647 - 258 WP_000343085.1 hypothetical protein -
NFK96_RS22340 (NFK96_22295) 25001..27139 + 2139 WP_000350638.1 AAA family ATPase -
NFK96_RS22345 (NFK96_22300) 27301..27717 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
NFK96_RS22350 (NFK96_22305) 27714..27944 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NFK96_RS22355 (NFK96_22310) 28240..28530 + 291 WP_000111771.1 hypothetical protein -
NFK96_RS22360 (NFK96_22315) 28520..29419 + 900 WP_000963206.1 nucleotide-binding protein -
NFK96_RS22365 (NFK96_22320) 29469..31694 - 2226 WP_000698737.1 P-loop NTPase fold protein -
NFK96_RS22370 (NFK96_22325) 31696..32784 - 1089 WP_000952217.1 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sitABCD - 1..90815 90815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T248517 WP_001044768.1 NZ_CP099333:c27717-27301 [Escherichia fergusonii]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT248517 WP_001261287.1 NZ_CP099333:c27944-27714 [Escherichia fergusonii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References