Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid unnamed2
Accession NZ_CP099333
Organism Escherichia fergusonii strain RHB44-C03

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NFK96_RS22215 Protein ID WP_244442846.1
Coordinates 2255..2533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag NFK96_RS22210 Protein ID WP_000079941.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK96_RS22200 (NFK96_22155) 46..1077 + 1032 WP_000907873.1 plasmid replication initiator RepA -
NFK96_RS22205 (NFK96_22160) 1773..1931 + 159 WP_000841008.1 hypothetical protein -
NFK96_RS22210 (NFK96_22165) 1986..2255 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NFK96_RS22215 (NFK96_22170) 2255..2533 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
NFK96_RS22220 (NFK96_22175) 2573..3421 + 849 WP_001057996.1 3'-5' exonuclease -
NFK96_RS22225 (NFK96_22180) 3538..4011 + 474 WP_001334658.1 hypothetical protein -
NFK96_RS22230 (NFK96_22185) 4070..5608 - 1539 WP_001547431.1 IS66-like element ISEc8 family transposase -
NFK96_RS22235 (NFK96_22190) 5658..6005 - 348 WP_000612591.1 IS66 family insertion sequence element accessory protein TnpB -
NFK96_RS22240 (NFK96_22195) 6002..6382 - 381 WP_072157534.1 transposase -
NFK96_RS22245 (NFK96_22200) 6938..7204 - 267 WP_000955263.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sitABCD - 1..90815 90815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T248516 WP_244442846.1 NZ_CP099333:2255-2533 [Escherichia fergusonii]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT248516 WP_000079941.1 NZ_CP099333:1986-2255 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References