Detailed information of TA system TA024850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 404652..405103
• Replicon: chromosome
• Accession: NC_014330
• Organism: Brachyspira pilosicoli 95/1000

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BP951000_RS01755
• Protein ID: WP_041747496.1
• Coordinates: 404652..404885 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: D8IB43
• Locus tag: BP951000_RS01760
• Protein ID: WP_013243321.1
• Coordinates: 404882..405103 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BP951000_RS01745	400292..402709	+	2418	WP_013243318.1	PBP1A family penicillin-binding protein	-
BP951000_RS01750	402716..404569	+	1854	WP_013243319.1	conjugal transfer protein TraB	-
BP951000_RS01755	404652..404885	-	234	WP_041747496.1	type II toxin-antitoxin system HicA family toxin	Toxin
BP951000_RS01760	404882..405103	-	222	WP_013243321.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BP951000_RS01765	405218..406306	-	1089	WP_187287141.1	hypothetical protein	-
BP951000_RS01770	406778..407179	-	402	WP_041747500.1	Hsp20/alpha crystallin family protein	-
BP951000_RS01775	407491..407949	+	459	WP_013243324.1	large conductance mechanosensitive channel protein MscL	-
BP951000_RS01780	408086..409231	+	1146	WP_013243325.1	alanine--glyoxylate aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-70)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 9036.71 Da
• Isoelectric Point: 10.1753

>T24850 WP_041747496.1 NC_014330:c404885-404652 [Brachyspira pilosicoli 95/1000]
MSKLILKDAKTIEKLLFLLGFVKHRQKGSHAFYKHEDGRCTVIPFHSSKVISRPLMRKILNEINLDVEEYNNLIEKI

Nucleotide

• Length: 234 bp

>T24850 NC_014330:c404885-404652 [Brachyspira pilosicoli 95/1000]
ATGAGTAAGCTAATTTTGAAGGACGCAAAAACTATAGAAAAATTGCTGTTTTTATTAGGGTTTGTTAAACATAGGCAGAA
AGGAAGTCATGCCTTTTATAAACATGAGGACGGACGATGCACCGTTATACCTTTTCACTCAAGCAAGGTAATATCAAGAC
CGCTTATGAGAAAAATATTAAATGAAATAAATCTTGATGTAGAAGAATATAATAATCTTATAGAAAAAATTTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8551.86 Da
• Isoelectric Point: 4.3348

>AT24850 WP_013243321.1 NC_014330:c405103-404882 [Brachyspira pilosicoli 95/1000]
MKKKFFAYIEYDKETNVYVGYIPSIVGAHTQADTLEELHIKLKEVLDLCLEEMDSEEKKTIPEFVKVEEIELV

Nucleotide

• Length: 222 bp

>AT24850 NC_014330:c405103-404882 [Brachyspira pilosicoli 95/1000]
ATGAAGAAAAAGTTTTTTGCATATATAGAATATGATAAAGAAACCAATGTTTATGTGGGATATATTCCTTCAATAGTTGG
GGCACATACACAGGCTGACACTTTGGAAGAGTTGCATATAAAATTAAAAGAGGTTTTGGATTTATGTCTTGAAGAGATGG
ACAGCGAAGAAAAGAAGACTATTCCAGAGTTTGTAAAAGTAGAAGAGATAGAGCTTGTATGA

Structures

Antitoxin

• AlphaFold DB: A0A381A9L8