Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3493889..3494543 Replicon chromosome
Accession NZ_CP099331
Organism Escherichia fergusonii strain RHB44-C03

Toxin (Protein)


Gene name cptA Uniprot ID F0JPE9
Locus tag NFK96_RS16760 Protein ID WP_000244774.1
Coordinates 3493889..3494296 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NFK96_RS16765 Protein ID WP_000354046.1
Coordinates 3494277..3494543 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK96_RS16740 (3489846) 3489846..3491579 - 1734 WP_223684717.1 single-stranded-DNA-specific exonuclease RecJ -
NFK96_RS16745 (3491585) 3491585..3492295 - 711 WP_000715223.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK96_RS16750 (3492320) 3492320..3493216 - 897 WP_196233981.1 site-specific tyrosine recombinase XerD -
NFK96_RS16755 (3493328) 3493328..3493849 + 522 WP_001055874.1 flavodoxin FldB -
NFK96_RS16760 (3493889) 3493889..3494296 - 408 WP_000244774.1 protein YgfX Toxin
NFK96_RS16765 (3494277) 3494277..3494543 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NFK96_RS16770 (3494795) 3494795..3495775 + 981 WP_223684718.1 tRNA-modifying protein YgfZ -
NFK96_RS16775 (3495852) 3495852..3496511 - 660 WP_000250283.1 hemolysin III family protein -
NFK96_RS16780 (3496675) 3496675..3496986 - 312 WP_181590787.1 N(4)-acetylcytidine aminohydrolase -
NFK96_RS16785 (3497031) 3497031..3498464 + 1434 WP_279284606.1 6-phospho-beta-glucosidase BglA -
NFK96_RS16790 (3498512) 3498512..3499405 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16078.05 Da        Isoelectric Point: 11.2511

>T248499 WP_000244774.1 NZ_CP099331:c3494296-3493889 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT248499 WP_000354046.1 NZ_CP099331:c3494543-3494277 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZX35

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References