Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3857834..3858410 Replicon chromosome
Accession NZ_CP099328
Organism Escherichia fergusonii strain RHB44-C21

Toxin (Protein)


Gene name shpA Uniprot ID A0A7W3EF74
Locus tag NFL02_RS18500 Protein ID WP_024256534.1
Coordinates 3858123..3858410 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag NFL02_RS18495 Protein ID WP_000063156.1
Coordinates 3857834..3858136 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL02_RS18475 (3853648) 3853648..3854160 + 513 WP_279283988.1 4-hydroxyphenylacetate 3-monooxygenase reductase subunit -
NFL02_RS18480 (3854430) 3854430..3856580 + 2151 WP_001314407.1 pyruvate/proton symporter BtsT -
NFL02_RS18485 (3856630) 3856630..3856833 + 204 WP_000467859.1 YbdD/YjiX family protein -
NFL02_RS18490 (3856844) 3856844..3857800 + 957 WP_001297640.1 GTPase -
NFL02_RS18495 (3857834) 3857834..3858136 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
NFL02_RS18500 (3858123) 3858123..3858410 - 288 WP_024256534.1 BrnT family toxin Toxin
NFL02_RS18505 (3858566) 3858566..3859300 - 735 WP_279283989.1 Fic family protein -
NFL02_RS18510 (3859563) 3859563..3863075 + 3513 WP_279283990.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11241.74 Da        Isoelectric Point: 7.4020

>T248477 WP_024256534.1 NZ_CP099328:c3858410-3858123 [Escherichia fergusonii]
MPMEFEWDANKAKSNRMKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT248477 WP_000063156.1 NZ_CP099328:c3858136-3857834 [Escherichia fergusonii]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3EF74

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References