Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3535807..3536461 Replicon chromosome
Accession NZ_CP099328
Organism Escherichia fergusonii strain RHB44-C21

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NFL02_RS17000 Protein ID WP_000244781.1
Coordinates 3535807..3536214 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NFL02_RS17005 Protein ID WP_000354046.1
Coordinates 3536195..3536461 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL02_RS16980 (3531764) 3531764..3533497 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
NFL02_RS16985 (3533503) 3533503..3534213 - 711 WP_046076902.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFL02_RS16990 (3534238) 3534238..3535134 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NFL02_RS16995 (3535246) 3535246..3535767 + 522 WP_001055874.1 flavodoxin FldB -
NFL02_RS17000 (3535807) 3535807..3536214 - 408 WP_000244781.1 protein YgfX Toxin
NFL02_RS17005 (3536195) 3536195..3536461 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NFL02_RS17010 (3536713) 3536713..3537693 + 981 WP_181590786.1 tRNA-modifying protein YgfZ -
NFL02_RS17015 (3537770) 3537770..3538429 - 660 WP_000250283.1 hemolysin III family protein -
NFL02_RS17020 (3538593) 3538593..3538904 - 312 WP_181590787.1 N(4)-acetylcytidine aminohydrolase -
NFL02_RS17025 (3538949) 3538949..3540382 + 1434 WP_024256637.1 6-phospho-beta-glucosidase BglA -
NFL02_RS17030 (3540430) 3540430..3541323 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T248475 WP_000244781.1 NZ_CP099328:c3536214-3535807 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT248475 WP_000354046.1 NZ_CP099328:c3536461-3536195 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References