Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3293144..3293763 Replicon chromosome
Accession NZ_CP099328
Organism Escherichia fergusonii strain RHB44-C21

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFL02_RS15870 Protein ID WP_001280991.1
Coordinates 3293545..3293763 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NFL02_RS15865 Protein ID WP_104917851.1
Coordinates 3293144..3293518 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL02_RS15855 (3288276) 3288276..3289469 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFL02_RS15860 (3289492) 3289492..3292641 + 3150 WP_001132493.1 efflux RND transporter permease AcrB -
NFL02_RS15865 (3293144) 3293144..3293518 + 375 WP_104917851.1 Hha toxicity modulator TomB Antitoxin
NFL02_RS15870 (3293545) 3293545..3293763 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NFL02_RS15875 (3294260) 3294260..3294730 + 471 WP_181591585.1 YlaC family protein -
NFL02_RS15880 (3294869) 3294869..3296419 + 1551 WP_001260376.1 EAL domain-containing protein -
NFL02_RS15885 (3296461) 3296461..3296814 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NFL02_RS15895 (3297193) 3297193..3297504 + 312 WP_000409911.1 MGMT family protein -
NFL02_RS15900 (3297535) 3297535..3298107 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248474 WP_001280991.1 NZ_CP099328:3293545-3293763 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14511.31 Da        Isoelectric Point: 4.8989

>AT248474 WP_104917851.1 NZ_CP099328:3293144-3293518 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References