Detailed information of TA system TA024847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 3070092..3070794
• Replicon: chromosome
• Accession: NC_014323
• Organism: Herbaspirillum seropedicae SmR1

Toxin (Protein)

• Gene name: tad
• Uniprot ID: D8IXT6
• Locus tag: HSERO_RS13510
• Protein ID: WP_013234666.1
• Coordinates: 3070092..3070478 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: HSERO_RS13515
• Protein ID: WP_041311942.1
• Coordinates: 3070459..3070794 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSERO_RS13480	3065120..3066142	-	1023	WP_041310849.1	TRAP transporter substrate-binding protein DctP	-
HSERO_RS13485	3066289..3066957	+	669	WP_013234661.1	GntR family transcriptional regulator	-
HSERO_RS13490	3066969..3067868	-	900	WP_013234662.1	pseudouridine synthase	-
HSERO_RS13495	3067865..3069205	-	1341	WP_013234663.1	type II toxin-antitoxin system HipA family toxin	-
HSERO_RS13500	3069202..3069504	-	303	WP_013234664.1	helix-turn-helix domain-containing protein	-
HSERO_RS13505	3069690..3069878	-	189	WP_013234665.1	YjfB family protein	-
HSERO_RS13510	3070092..3070478	+	387	WP_013234666.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HSERO_RS13515	3070459..3070794	+	336	WP_041311942.1	helix-turn-helix domain-containing protein	Antitoxin
HSERO_RS13520	3070874..3071062	-	189	WP_041311945.1	hypothetical protein	-
HSERO_RS13525	3071245..3072081	-	837	WP_013234669.1	anti-sigma factor	-
HSERO_RS13530	3072078..3072632	-	555	WP_048348571.1	RNA polymerase sigma factor	-
HSERO_RS13535	3072656..3073027	-	372	WP_013234671.1	hypothetical protein	-
HSERO_RS13540	3073140..3073574	-	435	WP_013234672.1	group 1 truncated hemoglobin	-
HSERO_RS13545	3073586..3074569	-	984	WP_048348713.1	DUF3034 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-93)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14387.57 Da
• Isoelectric Point: 9.9479

>T24847 WP_013234666.1 NC_014323:3070092-3070478 [Herbaspirillum seropedicae SmR1]
MHGKEKPLEWIGSSYKDLMALPSAIRQRFGYALSLAQLGDRDDAAKVLRGFGDAGVLEIIEDEASGTYRAVYVIRFEEAV
FVLHCFQKKSKHGIATPKTDIDIIRTRLKVAAARAEELRHARHAKKNH

Nucleotide

• Length: 387 bp

>T24847 NC_014323:3070092-3070478 [Herbaspirillum seropedicae SmR1]
ATGCACGGTAAAGAAAAACCACTTGAATGGATAGGTAGCAGCTACAAGGACCTCATGGCACTGCCATCAGCCATTCGTCA
GCGCTTTGGTTATGCCCTATCGTTGGCACAACTGGGAGATCGCGACGACGCAGCCAAAGTTCTAAGAGGATTTGGAGACG
CAGGCGTGCTGGAAATCATTGAGGATGAGGCCAGCGGCACCTATCGGGCGGTGTACGTGATCAGGTTCGAAGAGGCGGTC
TTCGTCCTCCATTGCTTCCAGAAGAAAAGCAAGCACGGTATTGCCACCCCGAAAACCGACATCGATATCATACGGACACG
GCTGAAAGTCGCCGCCGCACGCGCAGAGGAGCTAAGACATGCACGACATGCAAAGAAGAACCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12276.35 Da
• Isoelectric Point: 10.3997

>AT24847 WP_041311942.1 NC_014323:3070459-3070794 [Herbaspirillum seropedicae SmR1]
MQRRTIDDTPILRSSDNVFADLGLPDADKLKIKTALVVEIRKALRTLGLTQQAAAKRMGISQPKVSGMMRGDFSNLSERK
LMDCLNRLGYDIEIKLHPTSAVQGHLTLTVA

Nucleotide

• Length: 336 bp

>AT24847 NC_014323:3070459-3070794 [Herbaspirillum seropedicae SmR1]
ATGCAAAGAAGAACCATTGACGACACCCCTATCTTGCGCAGTTCAGACAATGTCTTCGCCGACCTCGGTCTGCCCGATGC
GGACAAGCTCAAAATCAAGACTGCCCTGGTGGTTGAAATCCGCAAAGCCTTACGTACACTCGGACTCACCCAACAGGCCG
CAGCCAAGCGCATGGGGATCTCCCAACCCAAGGTGTCAGGCATGATGCGTGGCGATTTCAGCAATCTGTCGGAACGCAAG
CTGATGGATTGCCTGAACCGACTGGGCTATGACATCGAGATCAAATTGCATCCGACCAGCGCTGTTCAGGGTCACCTGAC
ATTGACGGTGGCGTGA

Structures

Toxin

• AlphaFold DB: D8IXT6