Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1367189..1367814 Replicon chromosome
Accession NZ_CP099328
Organism Escherichia fergusonii strain RHB44-C21

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NFL02_RS06505 Protein ID WP_000911329.1
Coordinates 1367416..1367814 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NFL02_RS06500 Protein ID WP_000450524.1
Coordinates 1367189..1367416 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL02_RS06475 (1362991) 1362991..1363461 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
NFL02_RS06480 (1363461) 1363461..1364033 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
NFL02_RS06485 (1364180) 1364180..1365058 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
NFL02_RS06490 (1365075) 1365075..1366109 + 1035 WP_046077201.1 outer membrane protein assembly factor BamC -
NFL02_RS06495 (1366321) 1366321..1367034 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NFL02_RS06500 (1367189) 1367189..1367416 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NFL02_RS06505 (1367416) 1367416..1367814 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NFL02_RS06510 (1367961) 1367961..1368824 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NFL02_RS06515 (1368839) 1368839..1370854 + 2016 WP_279284300.1 tRNA cytosine(34) acetyltransferase TmcA -
NFL02_RS06520 (1370928) 1370928..1371626 + 699 WP_000679802.1 esterase -
NFL02_RS06525 (1371719) 1371719..1371919 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T248469 WP_000911329.1 NZ_CP099328:1367416-1367814 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT248469 WP_000450524.1 NZ_CP099328:1367189-1367416 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References