Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3931812..3932469 Replicon chromosome
Accession NZ_CP099327
Organism Enterobacter ludwigii strain RHB47-SO-C03

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag NFL62_RS18830 Protein ID WP_014171514.1
Coordinates 3931812..3932222 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NFL62_RS18835 Protein ID WP_003863437.1
Coordinates 3932203..3932469 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL62_RS18810 (NFL62_18805) 3927810..3929543 - 1734 WP_044866092.1 single-stranded-DNA-specific exonuclease RecJ -
NFL62_RS18815 (NFL62_18810) 3929549..3930262 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFL62_RS18820 (NFL62_18815) 3930286..3931182 - 897 WP_279257832.1 site-specific tyrosine recombinase XerD -
NFL62_RS18825 (NFL62_18820) 3931284..3931805 + 522 WP_014171513.1 flavodoxin FldB -
NFL62_RS18830 (NFL62_18825) 3931812..3932222 - 411 WP_014171514.1 protein YgfX Toxin
NFL62_RS18835 (NFL62_18830) 3932203..3932469 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NFL62_RS18840 (NFL62_18835) 3932764..3933744 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
NFL62_RS18845 (NFL62_18840) 3933855..3934514 - 660 WP_014171517.1 hemolysin III family protein -
NFL62_RS18850 (NFL62_18845) 3934781..3935512 + 732 WP_020883729.1 MurR/RpiR family transcriptional regulator -
NFL62_RS18855 (NFL62_18850) 3935629..3937062 + 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T248464 WP_014171514.1 NZ_CP099327:c3932222-3931812 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT248464 WP_003863437.1 NZ_CP099327:c3932469-3932203 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References