Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1025671..1026291 Replicon chromosome
Accession NZ_CP099327
Organism Enterobacter ludwigii strain RHB47-SO-C03

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag NFL62_RS04915 Protein ID WP_014168902.1
Coordinates 1025671..1025889 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag NFL62_RS04920 Protein ID WP_020885187.1
Coordinates 1025917..1026291 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL62_RS04885 (NFL62_04890) 1021682..1021942 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
NFL62_RS04890 (NFL62_04895) 1021945..1022085 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NFL62_RS04895 (NFL62_04900) 1022082..1022792 - 711 WP_020885191.1 GNAT family protein -
NFL62_RS04900 (NFL62_04905) 1022893..1024353 + 1461 WP_279258074.1 PLP-dependent aminotransferase family protein -
NFL62_RS04905 (NFL62_04910) 1024325..1024792 - 468 WP_020885189.1 YlaC family protein -
NFL62_RS04910 (NFL62_04915) 1024910..1025461 - 552 WP_020885188.1 maltose O-acetyltransferase -
NFL62_RS04915 (NFL62_04920) 1025671..1025889 - 219 WP_014168902.1 HHA domain-containing protein Toxin
NFL62_RS04920 (NFL62_04925) 1025917..1026291 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
NFL62_RS04925 (NFL62_04930) 1026803..1029949 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit AcrB -
NFL62_RS04930 (NFL62_04935) 1029972..1031165 - 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T248459 WP_014168902.1 NZ_CP099327:c1025889-1025671 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT248459 WP_020885187.1 NZ_CP099327:c1026291-1025917 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References