Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 41115..41854 Replicon plasmid unnamed1
Accession NZ_CP099326
Organism Enterobacter ludwigii strain RHB47-SO-C01

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NFL61_RS23025 Protein ID WP_259142916.1
Coordinates 41115..41600 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag NFL61_RS23030 Protein ID WP_259142918.1
Coordinates 41588..41854 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL61_RS23010 (NFL61_23005) 36352..38121 - 1770 WP_279259405.1 E2/UBC family protein -
NFL61_RS23015 (NFL61_23010) 38121..39419 - 1299 WP_279259406.1 CBASS cGAMP synthase -
NFL61_RS23020 (NFL61_23015) 39419..40492 - 1074 WP_279259407.1 CBASS cGAMP-activated phospholipase -
NFL61_RS23025 (NFL61_23020) 41115..41600 - 486 WP_259142916.1 GNAT family N-acetyltransferase Toxin
NFL61_RS23030 (NFL61_23025) 41588..41854 - 267 WP_259142918.1 DUF1778 domain-containing protein Antitoxin
NFL61_RS23035 (NFL61_23030) 42890..43933 + 1044 WP_259143065.1 plasmid replication initiator RepA -
NFL61_RS23040 (NFL61_23035) 44813..45304 + 492 WP_259142920.1 hypothetical protein -
NFL61_RS23045 (NFL61_23040) 45323..45745 + 423 WP_259142922.1 hypothetical protein -
NFL61_RS23050 (NFL61_23045) 45885..46655 - 771 WP_279259408.1 TraX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..107629 107629


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17646.30 Da        Isoelectric Point: 9.5010

>T248457 WP_259142916.1 NZ_CP099326:c41600-41115 [Enterobacter ludwigii]
VGQVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGSTRTFVVCKTYTKQVVGFYSLATGSVNHVEATGSLRRNM
PDPIPVIILARLAVDASFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKSFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10095.47 Da        Isoelectric Point: 4.5141

>AT248457 WP_259142918.1 NZ_CP099326:c41854-41588 [Enterobacter ludwigii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVSDDAAVDKLL
ARKPQWDK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References