Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3488751..3489372 Replicon chromosome
Accession NZ_CP099323
Organism Enterobacter hormaechei strain RHB45-SO-C08

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag NFL40_RS16590 Protein ID WP_015571250.1
Coordinates 3489154..3489372 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag NFL40_RS16585 Protein ID WP_006809850.1
Coordinates 3488751..3489125 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL40_RS16575 (NFL40_16565) 3483879..3485072 + 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFL40_RS16580 (NFL40_16570) 3485095..3488241 + 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit AcrB -
NFL40_RS16585 (NFL40_16575) 3488751..3489125 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
NFL40_RS16590 (NFL40_16580) 3489154..3489372 + 219 WP_015571250.1 HHA domain-containing protein Toxin
NFL40_RS16595 (NFL40_16585) 3489580..3490131 + 552 WP_048966011.1 maltose O-acetyltransferase -
NFL40_RS16600 (NFL40_16590) 3490248..3490715 + 468 WP_048966010.1 YlaC family protein -
NFL40_RS16605 (NFL40_16595) 3490687..3492147 - 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
NFL40_RS16610 (NFL40_16600) 3492250..3492960 + 711 WP_048966166.1 GNAT family protein -
NFL40_RS16615 (NFL40_16605) 3492957..3493097 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NFL40_RS16620 (NFL40_16610) 3493100..3493360 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T248448 WP_015571250.1 NZ_CP099323:3489154-3489372 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT248448 WP_006809850.1 NZ_CP099323:3488751-3489125 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References