Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2297593..2298332 Replicon chromosome
Accession NZ_CP099323
Organism Enterobacter hormaechei strain RHB45-SO-C08

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NFL40_RS10835 Protein ID WP_063139083.1
Coordinates 2297847..2298332 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NFL40_RS10830 Protein ID WP_003857131.1
Coordinates 2297593..2297859 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL40_RS10805 (NFL40_10800) 2292687..2293265 + 579 WP_022648146.1 fimbrial protein -
NFL40_RS10810 (NFL40_10805) 2293289..2294425 + 1137 WP_048966029.1 type 1 fimbrial protein -
NFL40_RS10815 (NFL40_10810) 2294546..2295103 + 558 WP_023300131.1 OmpH family outer membrane protein -
NFL40_RS10820 (NFL40_10815) 2295082..2296470 - 1389 WP_048966028.1 MFS transporter -
NFL40_RS10825 (NFL40_10820) 2296600..2297529 + 930 WP_225303375.1 LysR family transcriptional regulator -
NFL40_RS10830 (NFL40_10825) 2297593..2297859 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NFL40_RS10835 (NFL40_10830) 2297847..2298332 + 486 WP_063139083.1 GNAT family N-acetyltransferase Toxin
NFL40_RS10840 (NFL40_10835) 2298908..2299672 - 765 WP_023300126.1 SDR family NAD(P)-dependent oxidoreductase -
NFL40_RS10845 (NFL40_10840) 2299768..2300790 - 1023 WP_023300125.1 alpha/beta hydrolase -
NFL40_RS10850 (NFL40_10845) 2301269..2302027 + 759 WP_241213044.1 LysR substrate-binding domain-containing protein -
NFL40_RS10855 (NFL40_10850) 2302119..2303018 + 900 WP_108367563.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17544.22 Da        Isoelectric Point: 9.6275

>T248447 WP_063139083.1 NZ_CP099323:2297847-2298332 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT248447 WP_003857131.1 NZ_CP099323:2297593-2297859 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References