Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 810778..811559 Replicon chromosome
Accession NZ_CP099323
Organism Enterobacter hormaechei strain RHB45-SO-C08

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NFL40_RS03955 Protein ID WP_048966570.1
Coordinates 811068..811559 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0FY21
Locus tag NFL40_RS03950 Protein ID WP_022649379.1
Coordinates 810778..811071 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL40_RS03935 (NFL40_03935) 807764..808078 - 315 WP_003862457.1 lipoprotein -
NFL40_RS03940 (NFL40_03940) 808254..808886 + 633 WP_199126764.1 response regulator transcription factor -
NFL40_RS03945 (NFL40_03945) 808883..810676 + 1794 WP_225303228.1 hybrid sensor histidine kinase/response regulator -
NFL40_RS03950 (NFL40_03950) 810778..811071 + 294 WP_022649379.1 DUF1778 domain-containing protein Antitoxin
NFL40_RS03955 (NFL40_03955) 811068..811559 + 492 WP_048966570.1 GNAT family N-acetyltransferase Toxin
NFL40_RS03960 (NFL40_03960) 811711..813405 - 1695 WP_048966569.1 hypothetical protein -
NFL40_RS03965 (NFL40_03965) 813402..815312 - 1911 WP_022649376.1 hypothetical protein -
NFL40_RS03970 (NFL40_03970) 815827..816279 + 453 WP_225303227.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 808254..816279 8025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17471.40 Da        Isoelectric Point: 8.1405

>T248440 WP_048966570.1 NZ_CP099323:811068-811559 [Enterobacter hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTMNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10959.58 Da        Isoelectric Point: 8.6351

>AT248440 WP_022649379.1 NZ_CP099323:810778-811071 [Enterobacter hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0FY21

References