Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2307726..2308465 Replicon chromosome
Accession NZ_CP099318
Organism Enterobacter hormaechei strain RHB45-SO-C02

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NFL35_RS11035 Protein ID WP_003857133.1
Coordinates 2307726..2308211 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NFL35_RS11040 Protein ID WP_003857131.1
Coordinates 2308199..2308465 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL35_RS11010 (NFL35_11000) 2303270..2304028 - 759 WP_017693420.1 trans-aconitate 2-methyltransferase -
NFL35_RS11015 (NFL35_11005) 2304113..2304697 - 585 WP_039270753.1 NUDIX domain-containing protein -
NFL35_RS11020 (NFL35_11010) 2304784..2305542 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NFL35_RS11025 (NFL35_11015) 2305647..2306939 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NFL35_RS11030 (NFL35_11020) 2306939..2307553 + 615 WP_080338042.1 NUDIX hydrolase -
NFL35_RS11035 (NFL35_11025) 2307726..2308211 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NFL35_RS11040 (NFL35_11030) 2308199..2308465 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NFL35_RS11045 (NFL35_11035) 2308529..2309458 - 930 WP_039270752.1 LysR family transcriptional regulator -
NFL35_RS11050 (NFL35_11040) 2309588..2310970 + 1383 WP_039270751.1 MFS transporter -
NFL35_RS11055 (NFL35_11045) 2310992..2311987 - 996 WP_015570513.1 DUF2891 domain-containing protein -
NFL35_RS11060 (NFL35_11050) 2311997..2312983 - 987 WP_023296632.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2294362..2308465 14103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T248430 WP_003857133.1 NZ_CP099318:c2308211-2307726 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT248430 WP_003857131.1 NZ_CP099318:c2308465-2308199 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References