248426

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3820430..3821087 Replicon chromosome
Accession NZ_CP099316
Organism Enterobacter hormaechei strain RHB44-SE-C02

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag NFL06_RS18420 Protein ID WP_017382887.1
Coordinates 3820430..3820840 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NFL06_RS18425 Protein ID WP_003863437.1
Coordinates 3820821..3821087 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL06_RS18400 (NFL06_18385) 3816428..3818161 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
NFL06_RS18405 (NFL06_18390) 3818167..3818880 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFL06_RS18410 (NFL06_18395) 3818909..3819805 - 897 WP_017692715.1 site-specific tyrosine recombinase XerD -
NFL06_RS18415 (NFL06_18400) 3819907..3820428 + 522 WP_015571793.1 flavodoxin FldB -
NFL06_RS18420 (NFL06_18405) 3820430..3820840 - 411 WP_017382887.1 protein YgfX Toxin
NFL06_RS18425 (NFL06_18410) 3820821..3821087 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NFL06_RS18430 (NFL06_18415) 3821382..3822362 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
NFL06_RS18435 (NFL06_18420) 3822474..3823133 - 660 WP_003863433.1 hemolysin III family protein -
NFL06_RS18440 (NFL06_18425) 3823400..3824131 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
NFL06_RS18445 (NFL06_18430) 3824248..3825681 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T248426 WP_017382887.1 NZ_CP099316:c3820840-3820430 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT248426 WP_003863437.1 NZ_CP099316:c3821087-3820821 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References