Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2830971..2831582 Replicon chromosome
Accession NZ_CP099316
Organism Enterobacter hormaechei strain RHB44-SE-C02

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag NFL06_RS13660 Protein ID WP_012906750.1
Coordinates 2830971..2831150 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6G3F240
Locus tag NFL06_RS13665 Protein ID WP_045339414.1
Coordinates 2831172..2831582 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL06_RS13640 (NFL06_13625) 2826836..2827711 + 876 WP_015570244.1 ATP-binding cassette domain-containing protein -
NFL06_RS13645 (NFL06_13630) 2827708..2828424 + 717 WP_017384431.1 ABC transporter ATP-binding protein -
NFL06_RS13650 (NFL06_13635) 2828590..2829060 + 471 WP_017384432.1 hypothetical protein -
NFL06_RS13655 (NFL06_13640) 2829066..2829992 - 927 WP_017384433.1 LysR substrate-binding domain-containing protein -
NFL06_RS13660 (NFL06_13645) 2830971..2831150 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
NFL06_RS13665 (NFL06_13650) 2831172..2831582 + 411 WP_045339414.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFL06_RS13670 (NFL06_13655) 2831664..2832230 + 567 WP_279262322.1 serine acetyltransferase -
NFL06_RS13675 (NFL06_13660) 2832234..2832656 - 423 WP_279262323.1 tail fiber assembly protein -
NFL06_RS13680 (NFL06_13665) 2832658..2835219 - 2562 WP_279262324.1 phage tail protein -
NFL06_RS13685 (NFL06_13670) 2835222..2835773 - 552 WP_023299876.1 phage tail protein I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA / gtrA / gtrB 2827720..2905751 78031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T248424 WP_012906750.1 NZ_CP099316:2830971-2831150 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14890.79 Da        Isoelectric Point: 4.3170

>AT248424 WP_045339414.1 NZ_CP099316:2831172-2831582 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A6G3F240

References