Detailed information of TA system TA024842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 3060799..3061301
• Replicon: chromosome
• Accession: NC_014315
• Organism: Nitrosococcus watsonii C-113

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D8KBH5
• Locus tag: NWAT_RS13970
• Protein ID: WP_013221687.1
• Coordinates: 3061047..3061301 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: D8KBH4
• Locus tag: NWAT_RS13965
• Protein ID: WP_013221686.1
• Coordinates: 3060799..3061050 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NWAT_RS16845	3057381..3057522	+	142	Protein_2779	type II toxin-antitoxin system YoeB family toxin	-
NWAT_RS13930	3057590..3057913	-	324	WP_198342219.1	type II toxin-antitoxin system HicB family antitoxin	-
NWAT_RS13935	3057963..3058613	-	651	WP_013221680.1	hypothetical protein	-
NWAT_RS13940	3058761..3059114	-	354	WP_013221681.1	type II toxin-antitoxin system HicB family antitoxin	-
NWAT_RS13945	3059111..3059353	-	243	WP_013221682.1	type II toxin-antitoxin system HicA family toxin	-
NWAT_RS16850	3059775..3059936	-	162	WP_013221683.1	hypothetical protein	-
NWAT_RS13955	3060179..3060451	+	273	WP_013221684.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
NWAT_RS13960	3060432..3060704	+	273	WP_013221685.1	Txe/YoeB family addiction module toxin	-
NWAT_RS13965	3060799..3061050	+	252	WP_013221686.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
NWAT_RS13970	3061047..3061301	+	255	WP_013221687.1	Txe/YoeB family addiction module toxin	Toxin
NWAT_RS13975	3061606..3062295	-	690	WP_013221688.1	DUF1294 domain-containing protein	-
NWAT_RS13980	3062292..3062504	-	213	WP_013221689.1	plasmid maintenance system killer protein	-
NWAT_RS13985	3062625..3063482	+	858	WP_013221690.1	DUF4743 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10238.78 Da
• Isoelectric Point: 9.6240

>T24842 WP_013221687.1 NC_014315:3061047-3061301 [Nitrosococcus watsonii C-113]
VKLVFAENAWDDYLYWQKTDKRILKRINTLIKHIAHEPFEGIGKPEPLKHALSGYWSRRINEEHRIVYKIQEDSLFIAQL
RYHY

Nucleotide

• Length: 255 bp

>T24842 NC_014315:3061047-3061301 [Nitrosococcus watsonii C-113]
GTGAAACTGGTCTTTGCCGAGAACGCATGGGATGACTACCTATACTGGCAGAAGACTGACAAAAGAATTCTTAAAAGAAT
CAATACGCTCATAAAGCACATTGCGCACGAACCCTTTGAGGGTATCGGGAAGCCTGAGCCACTAAAGCATGCACTCTCTG
GGTATTGGTCTCGGCGAATTAATGAAGAACACCGCATTGTGTACAAAATCCAAGAAGATTCTCTCTTCATTGCCCAGCTT
CGCTACCATTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9361.72 Da
• Isoelectric Point: 4.8603

>AT24842 WP_013221686.1 NC_014315:3060799-3061050 [Nitrosococcus watsonii C-113]
MESISYTAARSNLAKTMEQVCNDHAPIAITRKGESAVVMISMEDYQALEETAYLLRSPKNTRRLIESIAELEMGKGREKE
LLE

Nucleotide

• Length: 252 bp

>AT24842 NC_014315:3060799-3061050 [Nitrosococcus watsonii C-113]
ATGGAAAGCATAAGCTATACTGCCGCCCGCAGCAACCTTGCTAAGACGATGGAGCAAGTATGTAACGATCATGCCCCCAT
TGCGATAACCCGCAAGGGCGAAAGTGCCGTAGTTATGATATCTATGGAGGACTACCAGGCATTGGAGGAAACGGCCTACT
TGCTCAGAAGCCCCAAAAATACTAGGAGGCTGATTGAATCGATTGCTGAGTTAGAAATGGGCAAGGGACGCGAAAAAGAA
CTGCTGGAGTGA

Structures

Toxin

• AlphaFold DB: D8KBH5

Antitoxin

• AlphaFold DB: D8KBH4