Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 1695929..1696726 Replicon chromosome
Accession NZ_CP099316
Organism Enterobacter hormaechei strain RHB44-SE-C02

Toxin (Protein)


Gene name KacT Uniprot ID A0A4Q2R3N2
Locus tag NFL06_RS07970 Protein ID WP_032670168.1
Coordinates 1696205..1696726 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag NFL06_RS07965 Protein ID WP_015570876.1
Coordinates 1695929..1696198 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL06_RS07930 (NFL06_07925) 1691469..1691828 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
NFL06_RS07935 (NFL06_07930) 1691907..1692002 - 96 Protein_1537 transcriptional regulator -
NFL06_RS07940 (NFL06_07935) 1692155..1693396 + 1242 WP_039271154.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
NFL06_RS07945 (NFL06_07940) 1693429..1693656 - 228 WP_006809324.1 YccJ family protein -
NFL06_RS07950 (NFL06_07945) 1693675..1694271 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
NFL06_RS07955 (NFL06_07950) 1694663..1694833 + 171 WP_001273664.1 general stress protein -
NFL06_RS07960 (NFL06_07955) 1694950..1695855 + 906 WP_017693666.1 DMT family transporter -
NFL06_RS07965 (NFL06_07960) 1695929..1696198 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
NFL06_RS07970 (NFL06_07965) 1696205..1696726 + 522 WP_032670168.1 GNAT family N-acetyltransferase Toxin
NFL06_RS07975 (NFL06_07970) 1696785..1698107 - 1323 WP_045344078.1 pyrimidine utilization transport protein G -
NFL06_RS07980 (NFL06_07975) 1698129..1698620 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
NFL06_RS07985 (NFL06_07980) 1698633..1699223 - 591 WP_045344080.1 malonic semialdehyde reductase -
NFL06_RS07990 (NFL06_07985) 1699233..1700033 - 801 WP_048229399.1 pyrimidine utilization protein D -
NFL06_RS07995 (NFL06_07990) 1700041..1700427 - 387 WP_015570870.1 pyrimidine utilization protein C -
NFL06_RS08000 (NFL06_07995) 1700439..1701128 - 690 WP_045344084.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19437.18 Da        Isoelectric Point: 7.4318

>T248418 WP_032670168.1 NZ_CP099316:1696205-1696726 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT248418 WP_015570876.1 NZ_CP099316:1695929-1696198 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q2R3N2

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References