Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 617987..618563 Replicon chromosome
Accession NZ_CP099316
Organism Enterobacter hormaechei strain RHB44-SE-C02

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag NFL06_RS02960 Protein ID WP_015572580.1
Coordinates 617987..618274 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag NFL06_RS02965 Protein ID WP_017694570.1
Coordinates 618261..618563 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL06_RS02935 (NFL06_02935) 613075..613794 + 720 WP_017694573.1 winged helix-turn-helix domain-containing protein -
NFL06_RS02940 (NFL06_02940) 613944..614414 + 471 WP_015572576.1 MarR family transcriptional regulator -
NFL06_RS02945 (NFL06_02945) 614411..615478 + 1068 WP_026094404.1 HlyD family secretion protein -
NFL06_RS02950 (NFL06_02950) 615468..616544 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
NFL06_RS02955 (NFL06_02955) 616541..617812 - 1272 WP_017694571.1 DUF445 domain-containing protein -
NFL06_RS02960 (NFL06_02960) 617987..618274 + 288 WP_015572580.1 BrnT family toxin Toxin
NFL06_RS02965 (NFL06_02965) 618261..618563 + 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
NFL06_RS02970 (NFL06_02970) 618592..619230 - 639 WP_017694569.1 LysE family translocator -
NFL06_RS02975 (NFL06_02975) 619269..620021 - 753 WP_015572582.1 AraC family transcriptional regulator -
NFL06_RS02980 (NFL06_02980) 620175..621545 + 1371 WP_017694568.1 NAD-dependent succinate-semialdehyde dehydrogenase -
NFL06_RS02985 (NFL06_02985) 621727..622272 - 546 WP_006810254.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T248415 WP_015572580.1 NZ_CP099316:617987-618274 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT248415 WP_017694570.1 NZ_CP099316:618261-618563 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References