Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4622540..4623156 Replicon chromosome
Accession NZ_CP099314
Organism Enterobacter hormaechei strain RHB44-SE-C01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NFL05_RS22270 Protein ID WP_015569913.1
Coordinates 4622540..4622911 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag NFL05_RS22275 Protein ID WP_015569912.1
Coordinates 4622914..4623156 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL05_RS22255 (NFL05_22240) 4620040..4620942 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
NFL05_RS22260 (NFL05_22245) 4620939..4621574 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
NFL05_RS22265 (NFL05_22250) 4621571..4622500 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
NFL05_RS22270 (NFL05_22255) 4622540..4622911 - 372 WP_015569913.1 PIN domain-containing protein Toxin
NFL05_RS22275 (NFL05_22260) 4622914..4623156 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
NFL05_RS22280 (NFL05_22265) 4623355..4624275 + 921 WP_015569911.1 alpha/beta hydrolase -
NFL05_RS22285 (NFL05_22270) 4624284..4625225 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
NFL05_RS22290 (NFL05_22275) 4625270..4625707 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
NFL05_RS22295 (NFL05_22280) 4625704..4626585 - 882 WP_279262567.1 virulence factor BrkB family protein -
NFL05_RS22300 (NFL05_22285) 4626579..4627178 - 600 WP_017694048.1 glucose-1-phosphatase -
NFL05_RS22305 (NFL05_22290) 4627297..4628097 - 801 WP_045344666.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T248414 WP_015569913.1 NZ_CP099314:c4622911-4622540 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT248414 WP_015569912.1 NZ_CP099314:c4623156-4622914 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References