Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3820428..3821085 Replicon chromosome
Accession NZ_CP099314
Organism Enterobacter hormaechei strain RHB44-SE-C01

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag NFL05_RS18415 Protein ID WP_017382887.1
Coordinates 3820428..3820838 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NFL05_RS18420 Protein ID WP_003863437.1
Coordinates 3820819..3821085 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL05_RS18395 (NFL05_18380) 3816426..3818159 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
NFL05_RS18400 (NFL05_18385) 3818165..3818878 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFL05_RS18405 (NFL05_18390) 3818907..3819803 - 897 WP_017692715.1 site-specific tyrosine recombinase XerD -
NFL05_RS18410 (NFL05_18395) 3819905..3820426 + 522 WP_015571793.1 flavodoxin FldB -
NFL05_RS18415 (NFL05_18400) 3820428..3820838 - 411 WP_017382887.1 protein YgfX Toxin
NFL05_RS18420 (NFL05_18405) 3820819..3821085 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NFL05_RS18425 (NFL05_18410) 3821380..3822360 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
NFL05_RS18430 (NFL05_18415) 3822472..3823131 - 660 WP_003863433.1 hemolysin III family protein -
NFL05_RS18435 (NFL05_18420) 3823398..3824129 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
NFL05_RS18440 (NFL05_18425) 3824246..3825679 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T248413 WP_017382887.1 NZ_CP099314:c3820838-3820428 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT248413 WP_003863437.1 NZ_CP099314:c3821085-3820819 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References