Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 2830969..2831580 | Replicon | chromosome |
Accession | NZ_CP099314 | ||
Organism | Enterobacter hormaechei strain RHB44-SE-C01 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | D2TUP9 |
Locus tag | NFL05_RS13655 | Protein ID | WP_012906750.1 |
Coordinates | 2830969..2831148 (+) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A6G3F240 |
Locus tag | NFL05_RS13660 | Protein ID | WP_045339414.1 |
Coordinates | 2831170..2831580 (+) | Length | 137 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NFL05_RS13635 (NFL05_13620) | 2826834..2827709 | + | 876 | WP_015570244.1 | ATP-binding cassette domain-containing protein | - |
NFL05_RS13640 (NFL05_13625) | 2827706..2828422 | + | 717 | WP_017384431.1 | ABC transporter ATP-binding protein | - |
NFL05_RS13645 (NFL05_13630) | 2828588..2829058 | + | 471 | WP_017384432.1 | hypothetical protein | - |
NFL05_RS13650 (NFL05_13635) | 2829064..2829990 | - | 927 | WP_017384433.1 | LysR substrate-binding domain-containing protein | - |
NFL05_RS13655 (NFL05_13640) | 2830969..2831148 | + | 180 | WP_012906750.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
NFL05_RS13660 (NFL05_13645) | 2831170..2831580 | + | 411 | WP_045339414.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
NFL05_RS13665 (NFL05_13650) | 2831662..2832228 | + | 567 | WP_279262322.1 | serine acetyltransferase | - |
NFL05_RS13670 (NFL05_13655) | 2832232..2832654 | - | 423 | WP_279262323.1 | tail fiber assembly protein | - |
NFL05_RS13675 (NFL05_13660) | 2832656..2835217 | - | 2562 | WP_279262324.1 | phage tail protein | - |
NFL05_RS13680 (NFL05_13665) | 2835220..2835771 | - | 552 | WP_023299876.1 | phage tail protein I | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | fliA / gtrA / gtrB | 2827718..2905749 | 78031 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6644.85 Da Isoelectric Point: 10.9132
>T248411 WP_012906750.1 NZ_CP099314:2830969-2831148 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL
Download Length: 180 bp
Antitoxin
Download Length: 137 a.a. Molecular weight: 14890.79 Da Isoelectric Point: 4.3170
>AT248411 WP_045339414.1 NZ_CP099314:2831170-2831580 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR
Download Length: 411 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7D6XDK4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6G3F240 |