Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2310386..2311125 Replicon chromosome
Accession NZ_CP099314
Organism Enterobacter hormaechei strain RHB44-SE-C01

Toxin (Protein)


Gene name tacT Uniprot ID A0A801DRD7
Locus tag NFL05_RS11105 Protein ID WP_017693417.1
Coordinates 2310386..2310871 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NFL05_RS11110 Protein ID WP_003857131.1
Coordinates 2310859..2311125 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL05_RS11085 (NFL05_11075) 2306539..2307297 - 759 WP_279262821.1 trans-aconitate 2-methyltransferase -
NFL05_RS11090 (NFL05_11080) 2307382..2307966 - 585 WP_045329825.1 NUDIX domain-containing protein -
NFL05_RS11095 (NFL05_11085) 2308053..2308811 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NFL05_RS11100 (NFL05_11090) 2308916..2310208 + 1293 WP_048229549.1 glycosyl hydrolase family 28 protein -
NFL05_RS11105 (NFL05_11095) 2310386..2310871 - 486 WP_017693417.1 GNAT family N-acetyltransferase Toxin
NFL05_RS11110 (NFL05_11100) 2310859..2311125 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NFL05_RS11115 (NFL05_11105) 2311189..2312118 - 930 WP_017693416.1 LysR family transcriptional regulator -
NFL05_RS11120 (NFL05_11110) 2312248..2313630 + 1383 WP_045345182.1 MFS transporter -
NFL05_RS11125 (NFL05_11115) 2313652..2314647 - 996 WP_047735388.1 DUF2891 domain-containing protein -
NFL05_RS11130 (NFL05_11120) 2314657..2315643 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17570.26 Da        Isoelectric Point: 9.9658

>T248406 WP_017693417.1 NZ_CP099314:c2310871-2310386 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKTFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT248406 WP_003857131.1 NZ_CP099314:c2311125-2310859 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References