Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 1695927..1696724 Replicon chromosome
Accession NZ_CP099314
Organism Enterobacter hormaechei strain RHB44-SE-C01

Toxin (Protein)


Gene name KacT Uniprot ID A0A4Q2R3N2
Locus tag NFL05_RS07965 Protein ID WP_032670168.1
Coordinates 1696203..1696724 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag NFL05_RS07960 Protein ID WP_015570876.1
Coordinates 1695927..1696196 (+) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL05_RS07925 (NFL05_07920) 1691467..1691826 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
NFL05_RS07930 (NFL05_07925) 1691905..1692000 - 96 Protein_1536 transcriptional regulator -
NFL05_RS07935 (NFL05_07930) 1692153..1693394 + 1242 WP_039271154.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
NFL05_RS07940 (NFL05_07935) 1693427..1693654 - 228 WP_006809324.1 YccJ family protein -
NFL05_RS07945 (NFL05_07940) 1693673..1694269 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
NFL05_RS07950 (NFL05_07945) 1694661..1694831 + 171 WP_001273664.1 general stress protein -
NFL05_RS07955 (NFL05_07950) 1694948..1695853 + 906 WP_017693666.1 DMT family transporter -
NFL05_RS07960 (NFL05_07955) 1695927..1696196 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
NFL05_RS07965 (NFL05_07960) 1696203..1696724 + 522 WP_032670168.1 GNAT family N-acetyltransferase Toxin
NFL05_RS07970 (NFL05_07965) 1696783..1698105 - 1323 WP_045344078.1 pyrimidine utilization transport protein G -
NFL05_RS07975 (NFL05_07970) 1698127..1698618 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
NFL05_RS07980 (NFL05_07975) 1698631..1699221 - 591 WP_045344080.1 malonic semialdehyde reductase -
NFL05_RS07985 (NFL05_07980) 1699231..1700031 - 801 WP_048229399.1 pyrimidine utilization protein D -
NFL05_RS07990 (NFL05_07985) 1700039..1700425 - 387 WP_015570870.1 pyrimidine utilization protein C -
NFL05_RS07995 (NFL05_07990) 1700437..1701126 - 690 WP_045344084.1 pyrimidine utilization protein B -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(87-149)

Antitoxin

(2-88)


Sequences


Toxin        


Download         Length: 174 a.a.        Molecular weight: 19437.18 Da        Isoelectric Point: 7.4318

>T248405 WP_032670168.1 NZ_CP099314:1696203-1696724 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp


Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT248405 WP_015570876.1 NZ_CP099314:1695927-1696196 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4Q2R3N2


Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References