Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1114306..1114926 Replicon chromosome
Accession NZ_CP099314
Organism Enterobacter hormaechei strain RHB44-SE-C01

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag NFL05_RS05290 Protein ID WP_015571250.1
Coordinates 1114306..1114524 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag NFL05_RS05295 Protein ID WP_006809850.1
Coordinates 1114552..1114926 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL05_RS05260 (NFL05_05260) 1110318..1110578 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
NFL05_RS05265 (NFL05_05265) 1110581..1110721 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NFL05_RS05270 (NFL05_05270) 1110718..1111428 - 711 WP_279262676.1 GNAT family protein -
NFL05_RS05275 (NFL05_05275) 1111530..1112990 + 1461 WP_045349927.1 PLP-dependent aminotransferase family protein -
NFL05_RS05280 (NFL05_05280) 1112962..1113429 - 468 WP_023296041.1 YlaC family protein -
NFL05_RS05285 (NFL05_05285) 1113546..1114097 - 552 WP_015571251.1 maltose O-acetyltransferase -
NFL05_RS05290 (NFL05_05290) 1114306..1114524 - 219 WP_015571250.1 HHA domain-containing protein Toxin
NFL05_RS05295 (NFL05_05295) 1114552..1114926 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
NFL05_RS05300 (NFL05_05300) 1115437..1118583 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
NFL05_RS05305 (NFL05_05305) 1118606..1119799 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T248404 WP_015571250.1 NZ_CP099314:c1114524-1114306 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT248404 WP_006809850.1 NZ_CP099314:c1114926-1114552 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References