Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 617988..618564 Replicon chromosome
Accession NZ_CP099314
Organism Enterobacter hormaechei strain RHB44-SE-C01

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag NFL05_RS02955 Protein ID WP_015572580.1
Coordinates 617988..618275 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag NFL05_RS02960 Protein ID WP_017694570.1
Coordinates 618262..618564 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL05_RS02930 (NFL05_02930) 613076..613795 + 720 WP_017694573.1 winged helix-turn-helix domain-containing protein -
NFL05_RS02935 (NFL05_02935) 613945..614415 + 471 WP_015572576.1 MarR family transcriptional regulator -
NFL05_RS02940 (NFL05_02940) 614412..615479 + 1068 WP_026094404.1 HlyD family secretion protein -
NFL05_RS02945 (NFL05_02945) 615469..616545 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
NFL05_RS02950 (NFL05_02950) 616542..617813 - 1272 WP_017694571.1 DUF445 domain-containing protein -
NFL05_RS02955 (NFL05_02955) 617988..618275 + 288 WP_015572580.1 BrnT family toxin Toxin
NFL05_RS02960 (NFL05_02960) 618262..618564 + 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
NFL05_RS02965 (NFL05_02965) 618593..619231 - 639 WP_017694569.1 LysE family translocator -
NFL05_RS02970 (NFL05_02970) 619270..620022 - 753 WP_015572582.1 AraC family transcriptional regulator -
NFL05_RS02975 (NFL05_02975) 620176..621546 + 1371 WP_017694568.1 NAD-dependent succinate-semialdehyde dehydrogenase -
NFL05_RS02980 (NFL05_02980) 621728..622273 - 546 WP_006810254.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T248402 WP_015572580.1 NZ_CP099314:617988-618275 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT248402 WP_017694570.1 NZ_CP099314:618262-618564 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References