Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1033443..1034063 Replicon chromosome
Accession NZ_CP099311
Organism Enterobacter ludwigii strain RHB43-SE-C05

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag NFK84_RS04895 Protein ID WP_014168902.1
Coordinates 1033443..1033661 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag NFK84_RS04900 Protein ID WP_020885187.1
Coordinates 1033689..1034063 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK84_RS04865 (NFK84_04865) 1029454..1029714 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
NFK84_RS04870 (NFK84_04870) 1029717..1029857 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NFK84_RS04875 (NFK84_04875) 1029854..1030564 - 711 WP_014168897.1 GNAT family protein -
NFK84_RS04880 (NFK84_04880) 1030665..1032125 + 1461 WP_279261943.1 PLP-dependent aminotransferase family protein -
NFK84_RS04885 (NFK84_04885) 1032097..1032564 - 468 WP_020885189.1 YlaC family protein -
NFK84_RS04890 (NFK84_04890) 1032682..1033233 - 552 WP_020885188.1 maltose O-acetyltransferase -
NFK84_RS04895 (NFK84_04895) 1033443..1033661 - 219 WP_014168902.1 HHA domain-containing protein Toxin
NFK84_RS04900 (NFK84_04900) 1033689..1034063 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
NFK84_RS04905 (NFK84_04905) 1034575..1037721 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit AcrB -
NFK84_RS04910 (NFK84_04910) 1037744..1038937 - 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T248394 WP_014168902.1 NZ_CP099311:c1033661-1033443 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT248394 WP_020885187.1 NZ_CP099311:c1034063-1033689 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References