Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3811929..3812586 Replicon chromosome
Accession NZ_CP099310
Organism Enterobacter ludwigii strain RHB28-E3-C01

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag NFK33_RS18085 Protein ID WP_014171514.1
Coordinates 3811929..3812339 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NFK33_RS18090 Protein ID WP_003863437.1
Coordinates 3812320..3812586 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK33_RS18065 (NFK33_18065) 3807927..3809660 - 1734 WP_044866092.1 single-stranded-DNA-specific exonuclease RecJ -
NFK33_RS18070 (NFK33_18070) 3809666..3810379 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK33_RS18075 (NFK33_18075) 3810403..3811299 - 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
NFK33_RS18080 (NFK33_18080) 3811401..3811922 + 522 WP_014171513.1 flavodoxin FldB -
NFK33_RS18085 (NFK33_18085) 3811929..3812339 - 411 WP_014171514.1 protein YgfX Toxin
NFK33_RS18090 (NFK33_18090) 3812320..3812586 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NFK33_RS18095 (NFK33_18095) 3812881..3813861 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
NFK33_RS18100 (NFK33_18100) 3813972..3814631 - 660 WP_014171517.1 hemolysin III family protein -
NFK33_RS18105 (NFK33_18105) 3814898..3815629 + 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
NFK33_RS18110 (NFK33_18110) 3815746..3817179 + 1434 WP_063925570.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T248392 WP_014171514.1 NZ_CP099310:c3812339-3811929 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT248392 WP_003863437.1 NZ_CP099310:c3812586-3812320 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References