Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1043300..1043920 Replicon chromosome
Accession NZ_CP099310
Organism Enterobacter ludwigii strain RHB28-E3-C01

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag NFK33_RS04915 Protein ID WP_014168902.1
Coordinates 1043300..1043518 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag NFK33_RS04920 Protein ID WP_020885187.1
Coordinates 1043546..1043920 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK33_RS04885 (NFK33_04885) 1039311..1039571 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
NFK33_RS04890 (NFK33_04890) 1039574..1039714 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NFK33_RS04895 (NFK33_04895) 1039711..1040421 - 711 WP_279256708.1 GNAT family protein -
NFK33_RS04900 (NFK33_04900) 1040522..1041982 + 1461 WP_020885190.1 PLP-dependent aminotransferase family protein -
NFK33_RS04905 (NFK33_04905) 1041954..1042421 - 468 WP_020885189.1 YlaC family protein -
NFK33_RS04910 (NFK33_04910) 1042539..1043090 - 552 WP_163306289.1 maltose O-acetyltransferase -
NFK33_RS04915 (NFK33_04915) 1043300..1043518 - 219 WP_014168902.1 HHA domain-containing protein Toxin
NFK33_RS04920 (NFK33_04920) 1043546..1043920 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
NFK33_RS04925 (NFK33_04925) 1044432..1047578 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit AcrB -
NFK33_RS04930 (NFK33_04930) 1047601..1048794 - 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T248387 WP_014168902.1 NZ_CP099310:c1043518-1043300 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT248387 WP_020885187.1 NZ_CP099310:c1043920-1043546 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References