Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3871863..3872520 Replicon chromosome
Accession NZ_CP099308
Organism Enterobacter roggenkampii strain RHB21-E1-C01

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag NFK08_RS18615 Protein ID WP_021242050.1
Coordinates 3871863..3872273 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag NFK08_RS18620 Protein ID WP_006178375.1
Coordinates 3872254..3872520 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK08_RS18595 (NFK08_18590) 3867856..3869589 - 1734 WP_045351724.1 single-stranded-DNA-specific exonuclease RecJ -
NFK08_RS18600 (NFK08_18595) 3869595..3870308 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK08_RS18605 (NFK08_18600) 3870337..3871233 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
NFK08_RS18610 (NFK08_18605) 3871335..3871856 + 522 WP_008499710.1 flavodoxin FldB -
NFK08_RS18615 (NFK08_18610) 3871863..3872273 - 411 WP_021242050.1 protein YgfX Toxin
NFK08_RS18620 (NFK08_18615) 3872254..3872520 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
NFK08_RS18625 (NFK08_18620) 3872815..3873795 + 981 WP_047745992.1 tRNA-modifying protein YgfZ -
NFK08_RS18630 (NFK08_18625) 3873880..3874539 - 660 WP_032664328.1 hemolysin III family protein -
NFK08_RS18635 (NFK08_18630) 3874805..3875536 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
NFK08_RS18640 (NFK08_18635) 3875653..3877086 + 1434 WP_008499715.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T248377 WP_021242050.1 NZ_CP099308:c3872273-3871863 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT248377 WP_006178375.1 NZ_CP099308:c3872520-3872254 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References