Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1038164..1038784 Replicon chromosome
Accession NZ_CP099308
Organism Enterobacter roggenkampii strain RHB21-E1-C01

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag NFK08_RS04860 Protein ID WP_008499287.1
Coordinates 1038164..1038382 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag NFK08_RS04865 Protein ID WP_008499288.1
Coordinates 1038410..1038784 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK08_RS04830 (NFK08_04830) 1034177..1034437 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
NFK08_RS04835 (NFK08_04835) 1034440..1034580 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NFK08_RS04840 (NFK08_04840) 1034577..1035287 - 711 WP_248199361.1 GNAT family protein -
NFK08_RS04845 (NFK08_04845) 1035389..1036849 + 1461 WP_248199358.1 PLP-dependent aminotransferase family protein -
NFK08_RS04850 (NFK08_04850) 1036821..1037288 - 468 WP_008499285.1 YlaC family protein -
NFK08_RS04855 (NFK08_04855) 1037406..1037957 - 552 WP_248199355.1 maltose O-acetyltransferase -
NFK08_RS04860 (NFK08_04860) 1038164..1038382 - 219 WP_008499287.1 HHA domain-containing protein Toxin
NFK08_RS04865 (NFK08_04865) 1038410..1038784 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
NFK08_RS04870 (NFK08_04870) 1039294..1042440 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
NFK08_RS04875 (NFK08_04875) 1042463..1043656 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T248372 WP_008499287.1 NZ_CP099308:c1038382-1038164 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT248372 WP_008499288.1 NZ_CP099308:c1038784-1038410 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References