Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 241576..242172 Replicon chromosome
Accession NZ_CP099308
Organism Enterobacter roggenkampii strain RHB21-E1-C01

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag NFK08_RS01090 Protein ID WP_023293553.1
Coordinates 241870..242172 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837LKY9
Locus tag NFK08_RS01085 Protein ID WP_044598004.1
Coordinates 241576..241863 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK08_RS01080 (NFK08_01080) 239948..241579 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
NFK08_RS01085 (NFK08_01085) 241576..241863 - 288 WP_044598004.1 putative addiction module antidote protein Antitoxin
NFK08_RS01090 (NFK08_01090) 241870..242172 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK08_RS01095 (NFK08_01095) 242370..243242 + 873 WP_248199460.1 23S rRNA pseudouridine(2604) synthase RluF -
NFK08_RS01100 (NFK08_01100) 243243..243515 - 273 WP_014830263.1 DUF3811 domain-containing protein -
NFK08_RS01105 (NFK08_01105) 243566..244510 - 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
NFK08_RS01110 (NFK08_01110) 244616..246190 - 1575 WP_032675767.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T248371 WP_023293553.1 NZ_CP099308:c242172-241870 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10142.50 Da        Isoelectric Point: 5.6306

>AT248371 WP_044598004.1 NZ_CP099308:c241863-241576 [Enterobacter roggenkampii]
MHNLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB A0A837LKY9

References