Detailed information of TA system TA024837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2725616..2726160
• Replicon: chromosome
• Accession: NC_014315
• Organism: Nitrosococcus watsonii C-113

Toxin (Protein)

• Gene name: parE
• Uniprot ID: D8K9X2
• Locus tag: NWAT_RS12390
• Protein ID: WP_013221399.1
• Coordinates: 2725864..2726160 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D8K9X1
• Locus tag: NWAT_RS12385
• Protein ID: WP_013221398.1
• Coordinates: 2725616..2725864 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NWAT_RS15740	2720901..2721668	-	768	WP_013221394.1	class I SAM-dependent methyltransferase	-
NWAT_RS12370	2721728..2722597	-	870	WP_013221395.1	glycosyltransferase family 2 protein	-
NWAT_RS12375	2722685..2724634	-	1950	WP_013221396.1	hypothetical protein	-
NWAT_RS12380	2724741..2725169	-	429	WP_013221397.1	pilin	-
NWAT_RS12385	2725616..2725864	+	249	WP_013221398.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
NWAT_RS12390	2725864..2726160	+	297	WP_013221399.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NWAT_RS12395	2726584..2726781	+	198	Protein_2468	hypothetical protein	-
NWAT_RS12400	2726862..2727407	+	546	Protein_2469	helicase	-
NWAT_RS12405	2727451..2728026	+	576	WP_013221400.1	hypothetical protein	-
NWAT_RS12410	2728113..2729144	+	1032	WP_083781476.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (3-64)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11572.26 Da
• Isoelectric Point: 9.6940

>T24837 WP_013221399.1 NC_014315:2725864-2726160 [Nitrosococcus watsonii C-113]
MPDYRITPRASTDLKNIGRYTLKTWGRQQRNIYLKNLDKRFAWLAENPRLGKHRPDIQEGYYCFPQGAHLIFYLLREGGI
DIIGLPHQDMDILNHFNG

Nucleotide

• Length: 297 bp

>T24837 NC_014315:2725864-2726160 [Nitrosococcus watsonii C-113]
ATGCCTGATTATAGAATTACACCACGGGCAAGCACGGATTTAAAAAATATTGGGCGCTATACGCTCAAAACCTGGGGCCG
GCAGCAACGCAATATTTATCTAAAAAACCTTGATAAACGTTTTGCCTGGCTGGCGGAAAATCCGCGCCTAGGAAAGCACC
GGCCTGATATCCAAGAAGGTTATTATTGCTTTCCCCAGGGGGCGCATCTGATTTTTTATCTCCTGCGCGAGGGTGGCATT
GATATCATCGGTCTCCCTCACCAGGATATGGATATTCTGAATCATTTTAACGGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9134.23 Da
• Isoelectric Point: 5.7151

>AT24837 WP_013221398.1 NC_014315:2725616-2725864 [Nitrosococcus watsonii C-113]
MANTSLSLGEHWETFIKNKMASGRYGSASEVVRDALRLLEARESKLEALRAHLGQGAAQAQRGEFVENYSIEAVIAELDR
ER

Nucleotide

• Length: 249 bp

>AT24837 NC_014315:2725616-2725864 [Nitrosococcus watsonii C-113]
ATGGCCAATACCAGCCTAAGCCTTGGGGAGCACTGGGAAACTTTTATCAAGAATAAAATGGCCAGCGGGCGCTACGGTTC
CGCCAGCGAAGTCGTGCGCGATGCGCTGCGCTTGTTGGAAGCACGGGAAAGCAAGCTGGAGGCATTGCGGGCGCATTTAG
GGCAGGGGGCGGCACAGGCACAGCGCGGTGAGTTTGTTGAAAACTATTCCATCGAGGCGGTGATCGCCGAGTTAGATCGG
GAACGCTAA

Structures

Toxin

• AlphaFold DB: D8K9X2

Antitoxin

• AlphaFold DB: D8K9X1