Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 44026..44687 Replicon chromosome
Accession NZ_CP099308
Organism Enterobacter roggenkampii strain RHB21-E1-C01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NFK08_RS00220 Protein ID WP_023293716.1
Coordinates 44289..44687 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A156KC23
Locus tag NFK08_RS00215 Protein ID WP_032675702.1
Coordinates 44026..44292 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK08_RS00190 (NFK08_00190) 40091..41419 - 1329 WP_248199286.1 PTS sugar transporter subunit IIC -
NFK08_RS00195 (NFK08_00195) 41431..41745 - 315 WP_021242703.1 PTS sugar transporter subunit IIB -
NFK08_RS00200 (NFK08_00200) 42039..42989 + 951 WP_023293714.1 LacI family DNA-binding transcriptional regulator -
NFK08_RS00205 (NFK08_00205) 43040..43336 - 297 WP_023326396.1 YicS family protein -
NFK08_RS00210 (NFK08_00210) 43477..43896 + 420 WP_008500129.1 GNAT family N-acetyltransferase -
NFK08_RS00215 (NFK08_00215) 44026..44292 + 267 WP_032675702.1 virulence protein Antitoxin
NFK08_RS00220 (NFK08_00220) 44289..44687 + 399 WP_023293716.1 type II toxin-antitoxin system VapC family toxin Toxin
NFK08_RS00225 (NFK08_00225) 44827..45627 + 801 WP_008500128.1 lipoprotein NlpA -
NFK08_RS00230 (NFK08_00230) 45750..46529 + 780 WP_248199285.1 MBL fold metallo-hydrolase -
NFK08_RS00235 (NFK08_00235) 46556..47509 + 954 WP_248199284.1 helix-turn-helix domain-containing protein -
NFK08_RS00240 (NFK08_00240) 47692..49389 + 1698 WP_248199329.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14799.00 Da        Isoelectric Point: 6.4779

>T248369 WP_023293716.1 NZ_CP099308:44289-44687 [Enterobacter roggenkampii]
MRHMLDTNIVSHLFKRHPEVVSRMTCLAPGDVCISSITEAELLYGADKKKSSRLKETIREFLNTITICDWDSDAAATYGE
LRATLEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFRMVQELAVEDWTTTL

Download         Length: 399 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10009.34 Da        Isoelectric Point: 4.6310

>AT248369 WP_032675702.1 NZ_CP099308:44026-44292 [Enterobacter roggenkampii]
MERTAKLFRKGQNQAVMLPAEFAFDTESVYIRRDEEGNVVLAAKPVLIKSWDNFLRMLAETDVPDTFLSKEERNQSVTTR
DPLDGACS

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A156KC23

References