248345

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4471281..4471947 Replicon chromosome
Accession NZ_CP099303
Organism Citrobacter freundii strain RHB02-E1-C01

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag NFJ16_RS21295 Protein ID WP_048216973.1
Coordinates 4471588..4471947 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0J1QJH0
Locus tag NFJ16_RS21290 Protein ID WP_032938223.1
Coordinates 4471281..4471598 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ16_RS21255 (4466460) 4466460..4467257 + 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -
NFJ16_RS21260 (4467269) 4467269..4468093 + 825 WP_048216971.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
NFJ16_RS21265 (4468161) 4468161..4469384 + 1224 WP_003031639.1 L-sorbose 1-phosphate reductase -
NFJ16_RS21270 (4469386) 4469386..4470198 + 813 WP_048216972.1 shikimate 5-dehydrogenase -
NFJ16_RS21275 (4470248) 4470248..4470604 - 357 WP_032938220.1 hypothetical protein -
NFJ16_RS21280 (4470736) 4470736..4470909 + 174 WP_032938222.1 hypothetical protein -
NFJ16_RS21285 (4470980) 4470980..4471141 + 162 WP_003841416.1 phage protein -
NFJ16_RS21290 (4471281) 4471281..4471598 - 318 WP_032938223.1 helix-turn-helix transcriptional regulator Antitoxin
NFJ16_RS21295 (4471588) 4471588..4471947 - 360 WP_048216973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ16_RS21300 (4472161) 4472161..4472850 + 690 WP_003841421.1 dipeptidase PepE -
NFJ16_RS21305 (4472916) 4472916..4474547 - 1632 WP_003031618.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13410.46 Da        Isoelectric Point: 10.2555

>T248345 WP_048216973.1 NZ_CP099303:c4471947-4471588 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11451.29 Da        Isoelectric Point: 6.9796

>AT248345 WP_032938223.1 NZ_CP099303:c4471598-4471281 [Citrobacter freundii]
MSHEVEASSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGEEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1QJH0

References