Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805672..806326 Replicon chromosome
Accession NZ_CP099303
Organism Citrobacter freundii strain RHB02-E1-C01

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag NFJ16_RS03925 Protein ID WP_003026936.1
Coordinates 805919..806326 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag NFJ16_RS03920 Protein ID WP_003026938.1
Coordinates 805672..805938 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ16_RS03895 (800873) 800873..802306 - 1434 WP_048217186.1 6-phospho-beta-glucosidase BglA -
NFJ16_RS03900 (802427) 802427..803155 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFJ16_RS03905 (803208) 803208..803519 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
NFJ16_RS03910 (803682) 803682..804341 + 660 WP_003838267.1 hemolysin III family protein -
NFJ16_RS03915 (804435) 804435..805415 - 981 WP_003838269.1 tRNA-modifying protein YgfZ -
NFJ16_RS03920 (805672) 805672..805938 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
NFJ16_RS03925 (805919) 805919..806326 + 408 WP_003026936.1 protein YgfX Toxin
NFJ16_RS03930 (806371) 806371..806892 - 522 WP_003026933.1 flavodoxin FldB -
NFJ16_RS03935 (807006) 807006..807902 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
NFJ16_RS03940 (807926) 807926..808639 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ16_RS03945 (808645) 808645..810378 + 1734 WP_032937435.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T248335 WP_003026936.1 NZ_CP099303:805919-806326 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT248335 WP_003026938.1 NZ_CP099303:805672-805938 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References