248333

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 253953..254584 Replicon chromosome
Accession NZ_CP099303
Organism Citrobacter freundii strain RHB02-E1-C01

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag NFJ16_RS01170 Protein ID WP_003837806.1
Coordinates 253953..254228 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag NFJ16_RS01175 Protein ID WP_003837808.1
Coordinates 254225..254584 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ16_RS01160 (250004) 250004..252751 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
NFJ16_RS01165 (252751) 252751..253875 + 1125 WP_003837801.1 ABC transporter permease -
NFJ16_RS01170 (253953) 253953..254228 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ16_RS01175 (254225) 254225..254584 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ16_RS01180 (254695) 254695..255096 - 402 WP_032937232.1 nickel-responsive transcriptional regulator NikR -
NFJ16_RS01185 (255146) 255146..255724 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
NFJ16_RS01190 (255787) 255787..256836 - 1050 WP_003023393.1 AI-2E family transporter -
NFJ16_RS01195 (256970) 256970..258187 + 1218 WP_048217067.1 MFS transporter -
NFJ16_RS01200 (258191) 258191..258748 - 558 WP_003837816.1 DcrB family lipoprotein -
NFJ16_RS01205 (258821) 258821..259486 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T248333 WP_003837806.1 NZ_CP099303:253953-254228 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT248333 WP_003837808.1 NZ_CP099303:254225-254584 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References