Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3801194..3801710 Replicon chromosome
Accession NZ_CP099298
Organism Citrobacter freundii strain RHB02-E3-C01

Toxin (Protein)


Gene name relE Uniprot ID A0A133L8K5
Locus tag NFJ20_RS18400 Protein ID WP_003844927.1
Coordinates 3801426..3801710 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag NFJ20_RS18395 Protein ID WP_003839576.1
Coordinates 3801194..3801436 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ20_RS18375 (3796209) 3796209..3797342 + 1134 WP_279273992.1 amidohydrolase/deacetylase family metallohydrolase -
NFJ20_RS18380 (3797326) 3797326..3798444 + 1119 WP_003025770.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NFJ20_RS18385 (3798441) 3798441..3799181 + 741 WP_003025772.1 KDGP aldolase family protein -
NFJ20_RS18390 (3799203) 3799203..3801116 + 1914 WP_003839574.1 BglG family transcription antiterminator -
NFJ20_RS18395 (3801194) 3801194..3801436 + 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFJ20_RS18400 (3801426) 3801426..3801710 + 285 WP_003844927.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ20_RS18405 (3801714) 3801714..3802178 - 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFJ20_RS18410 (3802363) 3802363..3804501 - 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
NFJ20_RS18415 (3804879) 3804879..3805463 - 585 WP_003844920.1 fructose PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10892.76 Da        Isoelectric Point: 10.0482

>T248329 WP_003844927.1 NZ_CP099298:3801426-3801710 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLLYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT248329 WP_003839576.1 NZ_CP099298:3801194-3801436 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133L8K5

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References